San Francisco 49ers @ Arizona Cardinals, University of Phoenix Stadium. 8:20 PM, FOX/NFLN (Cardinals +10, O/U: 43.5)
Jimmy G and Nicky B are taking a red hot 8-0 show on the road to Arizona. The Cardinals are ripe for the picking as Vegas gave a super juicy line to a banged up Cardinals offense. Kyler has wheels but can they help him avoid a surging Bosa? It’s a similar line (given the 3 point swap for being home) to the Saints line last week and we saw how that went with a less dangerous defense. Take the 49ers to cover in the over, 49ers 31-17.
Necessary Roughness 