Arizona Cardinals @ New Orleans Saints, Mercedes-Benz Superdome, 1:00 PM (Saints -12.5, O/U: 48.5)
Take the Cardinals to cover but the Saints to win in the under, Saints 24-17.
Cincinnati Bengals @ Los Angeles Rams, Wembley Stadium – London, 1:00 PM (Rams -12.5, O/U: 48.5)
Take the Rams to cover in the under, Rams 28-13.
Los Angeles Chargers @ Chicago Bears, Soldier Field, 1:00 PM (Bears -3.5, O/U: 41.5)
Take the Chargers to cover but the Bears to win, in the under, Bears 17-14.
New York Giants @ Detroit Lions, Ford Field, 1:00 PM (Lions -6, O/U: 49.5)
Take the Giants to cover but the Lions to win, in the under, Lions 24-20.
New York Jets @ Jacksonville Jaguars, TIAA Bank Field, 1:00 PM (Jaguars -7, O/U: 40.5)
Take the Jets to cover but the Jaguars to win in the under, Jaguars 27-23.
Denver Broncos @ Indianapolis Colts, Lucas Oil Stadium, 4:25 PM (Colts-5.5, O/U: 42.5)
Take the Colts to cover in the over, Colts 27-17.
Philadelphia Eagles @ Buffalo Bills, New Era Field, 1:00 PM (Bills -1, O/U: 40.5)
Take the Bills to cover in the over, Bills 23-20.
Seattle Seahawks @ Atlanta Falcons, Mercedes-Benz Superdome, 1:00 PM (Falcons +7.5, O/U: 50.5)
Take the Seahawks to cover in the over, Seahawks 34-17.
Tampa Bay Buccaneers @ Tennessee Titans, Nissan Stadium, 1:00 PM (Titans -2.5, O/U: 45.5)
Take the Titans to cover in the under, Titans 20-17.
Carolina Panthers @ San Francisco 49ers, Levi’s Stadium, 4:05 PM (49ers -4.5, O/U: 41.5)
Take the 49ers to cover in the over, 49ers 27-21.
Oakland Raiders @ Houston Texans, NRG Stadium, 4:25 PM (Texans -6.5, O/U: 52.5)
Take the Texans to cover in the over, Texans 31-24.
Cleveland Browns @ New England Patriots, Gillette Stadium, 4:25 PM (Patriots -10, O/U: 43.5)
Take the Patriots to cover in the over, Patriots 34-20.
Green Bay Packers @ Kansas City Chiefs, Arrowhead Stadium, 8:20 PM, NBC (Chiefs +4.5, O/U: 47.5)
Take the Packers to cover in the under, Packers 27-20.
Colin Cowherd’s Blazin’ 5:
- NY Giants at Detroit – NY Giants (+6.5)
- Oakland at Houston – Houston (-7)
- NY Jets at Jacksonville – NY Jets (+6.5)
- Carolina at San Francisco – Carolina (+6)
- Denver at Indianapolis – Indianapolis (-5)